Journal: Journal of Neurology, Neurosurgery, and Psychiatry
Article Title: Dynamics of synaptic damage in severe traumatic brain injury revealed by cerebrospinal fluid SNAP-25 and VILIP-1
doi: 10.1136/jnnp-2024-333413
Figure Lengend Snippet: Early synaptosomal-Associated protein 25 (SNAP-25) long-term prognosis on severe traumatic brain injury (TBI). ( A ) Strong trend towards higher levels of SNAP-25 at D2–D3 and D5–D6 in patients with unfavourable versus favourable outcome (Glasgow Outcome Scale Extended (GOSE) at 6 months 1–3 vs 4–8). ( B ) Comparison of visinin-like protein 1 (VILIP-1) values between favourable (4–8) or unfavourable (1–3) GOSE. ( C–F ) Principal component analysis (PCA) ( C,E ) and PCA vector ( D–F ) analysis for the favourable versus non-favourable outcome groups. The first two dimensions explain approximately 74% ( C ) to 78% ( E ) of variance. SNAP-25 and VILIP-1 vectors diverge from the other neuroaxonal and glial damage markers at D1 ( D ) but not at D5 ( F ). Each data point represents one patients/timepoint; median and IQR are depicted (black bars). Group size and significance are reported in the graphs. *P<0.05.
Article Snippet: The principal component analysis (PCA) was performed using R-studio software (V.4.3.1).
Techniques: Comparison, Plasmid Preparation